Wyandots and related tribes may number between 30,000 and 45,000, with two of the largest, the Attignousntan and the Attigneenongnahac, joined in a confederacy.Already at war with other Iroquoian tribes, the Wyandots begin to move west.1541 - May 8; Soto reaches the Mississippi River, having marched overland from the Floridas.
At the invitation of Sieur Antoine de la Mothe Cadillac, Wyandots move south from Michilimackinac to settle in the vicinity of the new fort, but pro- and anti-French (anti-Catholic) divisions persist.
Their influence greatly exceeds their numbers.1738 - The Wyandot chief Orontony, called Nicholas, has become estranged from the Ottawa and the French.
With his followers he leaves Detroit to establish a new village at Lower Sandusky (present Fremont, Ohio).
Capital of the confederacy is the town of Ossossane on Nottawasaga Bay.
Ottawa to Wyandot to Iroquois fur trade flourishes, supported by Wyandot agricultural surplus.