In June 2006, Francis began negotiating with the casting directors on the show to return to the role of Laura Spencer for a limited run through November.She returned with spectacular fanfare to commemorate the 25th anniversary of Luke and Laura's wedding.
The television supercouple Luke and Laura wed on November 17, 1981, with 30 million viewers tuning in to make the episode the highest-rated hour in soap opera history.
With her appearance, she was reunited with former General Hospital co-star Tristan Rogers, who portrayed Colin Atkinson, Cane's estranged biological father.
She received her second Daytime Emmy nomination in the category of Outstanding Supporting Actress in a Drama Series for her role as Genevieve in May 2012.
Francis decided to donate all of her proceeds/sales to this mission.
This endeavor was a project involving various members of her family.