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Its mechanisms of action are just beginning to be understood.

Our results suggest a new and feasible strategy for protection against cardiovascular disease.

Methods: Studies of aging and of the molecular effects of polyamines in general and spermidine in particular are used to synthesize our knowledge on what molecular mechanisms spermidine and other polyamines trigger to positively affect aging.

Results: Autophagy is the main mechanism of action of spermidine at the molecular level.

Abstract Background: Spermidine, a naturally occurring polyamine, has recently emerged as exhibiting anti-aging properties.

Its supplementation increases lifespan and resistance to stress, and decreases the occurrence of age-related pathology and loss of locomotor ability.

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